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KMID : 0191120180330060045
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Journal of Korean Medical Science
2018 Volume.33 No. 6 p.45 ~ p.45
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Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006?2010): a Retrospective Multicenter Study
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Rhie Kyu-Yol
Choi Eun-Hwa
Cho Eun-Young
Lee Ji-Na
Kang Jin-Han
Kim Dong-Soo
Kim Yae-Jean
Ahn Young-Min
Eun Byung-Wook
Oh Sung-Hee
Cha Sung-Ho
Hong Young-Jin
Kim Kwang-Nam
Kim Nam-Hee
Kim Yun-Kyung
Kim Jong-Hyun
Lee Taek-Jin
Kim Hwang-Min
Lee Kun-Song
Kim Chun-Soo
Park Su-Eun
Kim Young-Mi
Oh Chi-Eun
Ma Sang-Hyuk
Jo Dae-Sun
Choi Young-Youn
Lee Hoan-Jong
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Abstract
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Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea.
Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005.
Results: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996?2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001).
Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.
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KEYWORD
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Bacterial Infections, Epidemiology, Streptococcus agalactiae, Escherichia coli, Streptococcus pneumoniae, Staphylococcus aureus
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